The influence of pH and temperature on the degradation kinetics of 4-methoxy-2-[3-(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c] pyridine in aqueous solutions.
نویسندگان
چکیده
The pH-rate profiles for hydrolysis of 4-methoxy-2-[3-(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c] pyridine (H) at 333, 343, 353 and 363 K over the pH range 0.4-5.0 was investigated. The decomposition was followed by the HPLC method (LiChrosorb 100 RP-18 column 250 x 4.0 mm I.D., dp = 5 microm; mobile phase: acetonitrile-phosphate buffer (pH = 2; 0.01 mole/L) (45: 55, v/v or 30: 70, v/v). The pH-rate profile indicated specific acid- and base-catalysed reactions as well as spontaneous water-catalysed degradation of two molecules of II (as a dication and monocation). The ionic strength effect, the pKa value (2.4; 6.2), the pHmin value (2.1) and thermodynamic parameters of the reaction (energy and enthalpy of activation and the frequency coefficient for the specific rate constants) were determined.
منابع مشابه
Stability of new analgesic active compound, pyrrolo-[3,4-c]pyridine derivative, in aqueous solutions.
The kinetics of hydrolysis of 4-ethoxy-2-[2-hydroxy-3-(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine (III) in aqueous solutions at 333, 343, 353 and 363 K over the pH range 0.4-5.0 was investigated. The decomposition was observed by means of the HPLC method. A sample solution was chromatographed on octadecyl-packed column (LiChrosorb 100 RP-18 column 25...
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عنوان ژورنال:
- Acta poloniae pharmaceutica
دوره 62 2 شماره
صفحات -
تاریخ انتشار 2005